$499.00
In Stock
Temodal Lyophilisate for the preparation of infusion solution.
Temozolomide is an imidazotetrazine alkylating agent with antitumor activity. When entering the systemic circulation at physiological pH values, it undergoes rapid chemical transformation to form the active compound – monomethyltriazenoimidazolecarboxamide (MTIC). It is believed that the cytotoxicity of MTIC is primarily due to alkylation of guanine at position O6 and additional alkylation at position N7. Apparently, the resulting cytotoxic damage includes (triggers) the mechanism of aberrant reduction of the methyl residue.
Newly diagnosed glioblastoma multiforme – combination treatment with radiation therapy followed by adjuvant monotherapy.
Malignant glioma (glioblastoma multiforme or anaplastic astrocytoma), in the presence of relapse or progression of the disease after standard therapy.
Disseminated metastatic malignant melanoma – as a first-line therapeutic agent.
Active ingredient: temozolomide
The drug is delivered from Germany
Prescription medicine
