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The antitumor drug Yondelis is a tristetrahydroisoquinoline alkaloid of natural (marine) origin. The drug has a complex mechanism of action aimed at transcription. It represses gene transcription and interacts with the transcription-coupled nucleotide repair system.
Indications:
– ovarian cancer that recurs after therapy based on platinum derivatives (Yondelis is used as part of combination therapy with pegylated liposomal doxorubicin);
– common soft tissue sarcomas in patients insensitive to anthracyclines and ifosfamide, or with contraindications to their use; effectiveness is shown mainly in patients with liposarcoma and leiomyosarcoma
Active ingredient: trabectedin
Prescription medicine
Storage temperature 2-8 degrees
